Lonza sell "Solid Form Services"

Choosing the right lead solid form of an API is a pivotal early step in pharmaceutical development, since the chemical and physical form selected affects manufacturability, stability, and bioavailability. This process involves screening and characterizing chemical forms (free forms, salts, hydrates, solvates, and cocrystals) along with polymorphs and amorphous forms. Because each molecule differs in its tendency toward polymorphism and hydrate/solvate formation, the molecule's physicochemical properties and target product profile guide whether salt, cocrystal, or bioavailability-enhancing screening is needed, properties that in turn govern solubility, dissolution rate, and manufacturability. These solid form services are built for flexibility and can be used standalone or as part of an integrated drug substance/product program...