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Product Name

Linaclotide

Substance

Specifications

  • CAS Number: 851199-59-2
  • Chemical Formula: C59H79N15O21S6
  • Indication: Synthetic 14-amino-acid guanylate cyclase-C (GC-C) agonist for constipation-predominant IBS and chronic idiopathic constipation
  • IUPAC Name: (2S)-2-[[(1R,4S,7S,13S,16R,21R,24R,27S,30S,33R,38R,44S)-21-amino-13-(2-amino-2-oxoethyl)-27-(2-carboxyethyl)-44-[(1R)-1-hydroxyethyl]-30-[(4-hydroxyphenyl)methyl]-4-methyl-3,6,12,15,22,25,28,31,40,43,46,51-dodecaoxo-18,19,35,36,48,49-hexathia-2,5,11,14,23
  • EC Number: 812-291-9
  • Molecular Weight: 1526.8
  • Storage Conditions: Store refrigerated at 2-8°C, protected from light; do not freeze
  • Regulatory Approval Status: FDA-approved for treatment of IBS-C and chronic idiopathic constipation in adults

Other Information

Additional Description:

Linaclotide is a synthetic 14-amino-acid peptide related to the endogenous guanylin peptide family, and is the only FDA-approved, clinically available locally acting intestinal GC-C (guanylate cyclase-C) agonist for treating constipation-predominant IBS and chronic idiopathic constipation in adults.
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