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Sichuan Qingmu Pharmaceutical Co., Ltd sell "Firocoxib"

Basic Information

163
10
4
3.9(38)

Trade Type

Sell

Product Name

Firocoxib

Details

Substance

Specifications

  • EC Number: 837-109-5
  • Chemical Formula: C17H20O5S
  • CAS Number: 189954-96-9
  • IUPAC Name: 3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-methylsulfonylphenyl)furan-2-one
  • Molecular Weight: 336.4
  • Assay: ≥ 98.0% by HPLC (in-house/compendial assay method)
  • Impurity Profile: Complies with ICH Q3A/Q3B related-substance limits

Other Information

Additional Description:

Firocoxib is a selective COX-2 inhibitor (IC50 values of 0.13 microM for COX-2 and 7.5 microM for COX-1 in isolated cat blood) that suppresses LPS-induced prostaglandin E2 production in dog, horse, and cat whole blood ex vivo. In dogs and horses with osteoarthritis, it has been shown to reduce lameness, provide analgesia, and improve range of motion at doses of 5 mg/kg/day and 0.1 mg/kg/day respectively, and formulations containing it are used to manage osteoarthritis in these species.
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