Dennis A. Smith worked in the pharmaceutical industry for 32 years after gaining his Ph.D. from the University of Manchester. Much of this time was with Pfizer. During this period, he directly helped in the Discovery and Development of eight marketed NCEs. More recently his roles include advisory boards, expert panels and consultations with many drug research-based organizations, both industrial and academic. His career in drug discovery and development now spans over 50 years. His research interests and publications, which number over 200, including several books, span all aspects of drug discovery and development. In 2022 he received the ISSX Distinguished Accomplishments in Drug Discovery and Development award.